Cell-based assays and products based on primary human cells, for inflammation research. Enabling the generation of reliable, clinically-relevant human data in early drug discovery.
Target validation, preclinical efficacy, safety and candidate selection of small molecules or biologics using CellInsight™ human primary cell platform and mass spectrometry bioanalysis.
CellMade is discovering key biochemical inflammatory biomarkers that effectively predict clinical outcomes. Our IP portfolio includes biomarkers of anti-TNFα drug toxicity and inflammatory cytokine modulation.
Until now, most researchers have been using single or multi-cytokine activity assays, using ELISA or RT-PCR, or measuring TNFα or TNFα receptor levels to screen for compounds with the potential for anti-infectious or anti-inflammatory applications. You have to do a whole battery of follow-on experiments to find out just what your potential drug candidate might be triggering further downstream, and from there, its potential application. So what if we had a way to precisely monitor and differentiate the downstream effects of TNFα receptor activation, and see these effects within minutes of adding the compound to the screen? Lipid bioanalysis offers a way forward....
CellMade, a specialist provider of inflammatory cell biology products and services for biomarker and drug discovery, announces the launch of its new website. Reflecting the company’s leading position in using human cell-based technology to better inform research decisions, the new site features free poster and protocol downloads as well as updated information on the CellInsight™ platform and REACT-lipid™ service. www.cellmade.com looks set to become a primary resource for drug discovery and preclinical researchers working in inflammatory diseases.