Human primary synoviocytes from healthy individuals and rheumatoid arthritis patients. Provided for pharmaceutical R&D into RA and inflammatory response.
Fibroblast-like Synoviocytes (FLS) From Healthy Individuals and Arthritis Patients
Obtained from synovectomies of RA patients, osteoarthritis patients and healthy subjects, for research purposes. Fibroblast-like synoviocytes (FLS) actively participate in synovial inflammation. They can contribute to initiation, propagation, and maintenance of chronic inflammation by secreting cytokines, chemokines, growth factors and several other proinflammatory molecules such as prostaglandins and leukotrienes. As such, they are a target for therapeutic intervention in rheumatoid arthritis and osteoarthritis.
Download the product specification sheet: Human Fibroblast-Like Synoviocytes Product Spec Sheet Download the culture protocol: Human Fibroblast-Like Synoviocytes Culture Protocol
References:
- Noss EH, Brenner MB ; The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis; Immunol Rev. 2008 Jun,223,252-70.
- Beatrix Bartok, Gary S. Firestein; Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis; Immunol Rev. 2010 January , 233(1), 233–255.
If you’re interested in obtaining primary human synoviocytes for your rheumatoid arthritis or inflammatory disease research, please contact us.
